GH-axis research
GH Axis Protocol (CJC-1295 + Ipamorelin)
Why this combination exists
The two compounds trigger growth-hormone release through separate receptors — CJC-1295 amplifies the GHRH signal while Ipamorelin fires the ghrelin receptor — and research references the combined pulse as synergistic: greater than either alone at the same doses.
Both preserve the body's natural pulsatile release pattern, which is why the blend is dosed to coincide with the biggest natural pulse of the day: the first hours of sleep.
Literature-referenced schedule
| Component | Referenced schedule |
|---|---|
| CJC-1295 (no-DAC) + Ipamorelin | 250 mcg + 250 mcg, once nightly before bed on an empty stomach, 5 days on / 2 off (literature reference) |
| Cycle length | 8–12 week cycles referenced, followed by an equal break |
Reconstitution notes
Reconstitute to matching concentrations for easy same-syringe drawing: 2 mg CJC-1295 + 1 mL BAC = 2,000 mcg/mL (250 mcg = 12.5 units); 5 mg Ipamorelin + 2.5 mL BAC = 2,000 mcg/mL (250 mcg = 12.5 units). Both are fridge-stable ~28–30 days reconstituted — plan vial sizes so nothing outlives its window.
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Peptides in this protocol
CJC-1295
A growth-hormone-releasing hormone analog studied for stimulating GH release; often blended with Ipamorelin.
Full research profile →
Growth Hormone SecretagogueIpamorelin
A selective ghrelin-receptor agonist / GH secretagogue studied for stimulating GH with minimal effect on cortisol or prolactin.
Full research profile →
Frequently asked questions
Why 250/250 mcg specifically?
It is the saturation-range reference that dominates the literature — the point where research references diminishing returns from higher doses of either compound.
Why dose before bed on an empty stomach?
The body's largest natural GH pulse happens in early deep sleep, and elevated glucose or fatty acids blunt GH release. Empty-stomach evening dosing works with both facts.
Why 5 days on, 2 off?
A commonly referenced pattern intended to limit receptor desensitization while keeping the weekly rhythm simple.